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Read|Information source:SJZ kidney disease hospital|Published:2015-11-20


 Zheng Falei has taken up a job as a doctor for 40 years.

After 1979,he mainly engaged in the clinical research and teaching of Kidney Disease. The key points of that are metabolic disorders and nutritional therapy of Chronic Kidney Disease,pathogenesis and intervention of renal interstitial fibrosis,lesions on kidney tubules and Renal toxicity and so on.

In the 1980s and1990s,he reported firstly the disorder of protein,amino acid and used the essential amino acids and ketones acid to treat the Chronic Renal Disease(CKD). At the same time,he informed that this therapy can improve the metabolic disorders of protein and amino acids. Besides,it can also relieve the Kidney Disease process. It is worth mentioning that this research won the Second Prize of China Academy of Medical Sciences Research in 1985.

And then,in the Metabolism Study of chronic renal failure(CRF),he was the first to report the relationship between Metabolic Acidosis and orexin,leptin of patients with uremia.

After 1988,he report the Type IV clinical and biochemical characteristics of renal tubular acidosis firstly in China.

In 1991,with his peers, they take the basic and clinical research on erythrogenin,which was awarded Second Prize of National Scientific and Technological Progress.

In the study of renal toxicity mechanism,he discovered that the death caused by medicine is closely to the change of calcium ion concentration in cell,which made the partner and him awarded the Second Prize of Chinese Medicine in 2008.

After 1997,he took the research on the pathogenesis of Aristolochzc Acid Nephropathy(AAN). And he made the successful animal model of rats' Chronic Aristolochic Acid Nephropathy firstly. Then he also was the first one to report the transdifferentiation of renal tubular epithelial cells is one of the main pathogenesis of AAN.

In 2007,he won the 90th Anniversary of China Medical College Outstanding Paper Award. What's more,he also had undertook and accomplished some fund program such as the National Natural Science Foundation of China (NSFC),Beijing Natural Science Fund Project,Ministry of Science and Technology "five-year" and "five-year", "15" research projects and other Science Fund Project of Ministry of Health or CHINESE ACAD MED SCI.

Article URL:http://www.kidneyhospital.org/experts/787.html

TAG: Chronic Renal Failure,expert,kidney

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